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Immunity (2002) 16(6):76977

Glucagon receptor activation is the differentiator: it increases energy expenditure by stimulating thermogenesis and fat oxidation in the liver

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The most useful point for your readers is what the trial measured: percent change in body weight at defined time points responder thresholds such as achieving at least 5 percent reduction dose response relationships across multiple dose arms Eli Lillys release about the NEJM publication also highlights reported mean weight reduction at 24 weeks and continued reduction through 48 weeks in secondary endpoints, which is helpful for understanding the time course logic used in trial reporting