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8.4 Mercks Sitagliptin Synthesis: Biocatalysis as Process IP The synthesis of sitagliptin, the API in Januvia (Mercks DPP-4 inhibitor for type 2 diabetes), provides the pharmaceutical industrys most cited case study in applied biocatalysis
The obvious one, which we will dedicate most of the article to, is pregnancy
Before GLP treatment (blue curve), minimum HR initially increases slightly when exercise exceeds the rolling baseline but then declines substantially at very large deviations
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