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The scenarios where injectable GLP-1s are clearly superior: A1C above 9.0% (need for maximum efficacy) Established cardiovascular disease (need for proven MACE reduction) Primary goal is weight loss (need for higher semaglutide exposure) Difficulty with medication adherence (weekly is easier than daily for many patients) Unpredictable morning schedule (can't guarantee empty stomach timing) The decision is patient-specific

The IGF-1 component is unique and theoretically addresses the lean mass loss seen with all current GLP-1 therapies

Others need 15 mg for adequate weight loss and ultimately feel better at that dose once adapted

This pricing structure ensures you can titrate safely to your optimal therapeutic dose without cost barriers

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