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In placebo-controlled trials to improve glycemic control, cholelithiasis was reported in 1% of patients treated with RYBELSUS 7 mg
Researchers propose that GIP receptor activation may complement GLP-1 signaling effects on glucose metabolism, though the precise mechanisms in humans continue to be studied
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At 52 weeks, the group continuing tirzepatide experienced an additional 5.5% weight reduction, while the group who switched to the placebo regained 14% of their body weight
No direct head-to-head trial has been conducted, so these comparisons are drawn from separate trials with different populations and durations
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