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[8] The age-related decline and its implications The decline of circulating GHK from 200 ng/mL at age 20 to 80 ng/mL by age 60 correlates with reduced wound healing capacity, thinner skin, decreased collagen density, and slower tissue repair
doi: 10.1016/j.neuroscience.2013.01.035, 86
GHK-Cu is a copper-binding tripeptide investigated in connective-tissue and matrix-remodeling models
Key findings include: Upregulation of VEGFR2 expression and internalization in endothelial cells Activation of the VEGFR2-Akt-eNOS signaling cascade Enhanced endothelial cell proliferation and tube formation Improved collateral circulation in ischemic injury models The peptides pro-angiogenic effects appear particularly relevant in healing scenarios where blood supply restoration is critical for tissue recovery
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