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In a 48-week phase II clinical trial conducted on patients with type 2 diabetes and obesity, treatment with a dose of 10 mg/kg of bimagrumab resulted in a significant reduction in fat mass by 20.5% (compared to 0.5% in the placebo group), while lean body mass increased by 3.6% (as opposed to a decrease of 0.8% in the placebo group), leading to an overall body weight reduction of -6.5%, which was substantially better than the -0.8% observed in the placebo group
Diarrhoea can also occur, with clinical trials showing that 1 in 10 people can encounter it while taking Mounjaro
She said high doses of steroids are known to reduce bone density and increase infection rates, so researchers would need to investigate whether short bursts of the drugs could, over time, cause the same issues
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