Human Studies In humans a combination of 2 mg of melatonin plus 60 mg of vitamin C for females or 75 mg of vitamin C for males resulted in significant improvement in postoperative outcomes of periodontal disease at 6 months compared to 3 months and the non-treated group (2)
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Emerging therapeutic strategies targeting the gut microbiome include probiotics, prebiotics, synbiotics, postbiotics, and fecal microbiota transplantation (FMT)
Diabetes Care 35:12251231 Russell-Jones D, Cuddihy RM, Hanefeld M et al (2012) Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study
In 2017, another clinical study showed that melatonin intake (10 mg/day, P.O for 12 weeks) increased serum GSH levels while reducing serum MDA and protein carbonyl (PCO) in CHD patients with type 2 diabetes