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Some had been accused of taking the easy way out. I think that there is kind of a stigma that its a cop-out, one participant said, that youre just taking the easy way out rather than doing it with diet and exercise like you should. Reflecting on the findings, de Vere Hunt shares, I expected perceived stigma to be present for people taking GLP-1 RA medications, but I was surprised by how strongly it still emerged in interviews. A particularly important finding, she added, was that many participants felt society viewed GLP-1 use differently depending on the reason: diabetes treatment was seen as legitimate, while obesity treatment was often framed as cheating. Biologically this doesnt make much sense, de Vere Hunt said, as obesity is also a chronic disease involving dysregulated hormonal and metabolic pathways with serious long-term health implications. Yet eligibility criteria, she said, can reinforce the misconception that people do not need medical support to treat obesity alone

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However, off-label use does not mean the approach has been proven safe or effective

Bone morphogenetic protein 9 is a paracrine factor controlling liver sinusoidal endothelial cell fenestration and protecting against hepatic fibrosis

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