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With respect to dosage, the average reductions were: 2000 mcg: 71.5% (single data point) 1,000 mcg: 31.8% Although limited data are available for higher dosages, the findings support the efficacy of both oral and non-oral B12 formulations in modulating homocysteine levels

Symptoms of deficiencyfatigue, weakness, paraesthesia, cognitive impairment, and mood disturbancestypically improve significantly with appropriate replacement therapy

Failing to account for this when switching vial sizes is one of the most common and dangerous reconstitution errors