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Results demonstrated that AOD-9604 displayed a very good safety and tolerability profile indistinguishable from placebo. Critically, the peptide produced no clinically significant alterations in IGF-1 levels, no glucose intolerance or insulin resistance, and no anti-AOD9604 antibodies in any participant

Its targeted mechanism of action makes it a valuable compound for investigating how NNMT inhibition influences metabolic health, mitochondrial function, and longevity-associated biological processes

While many nootropic supplements are generally well-tolerated, individual responses can vary, and side effects such as headaches, digestive discomfort, dizziness, or sleep disturbances may occur, especially at higher doses or with prolonged use

Insomnia treatment studies looking at DSIP for insomnia have produced contradictory results