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Advances in Experimental Medicine and Biology, 681, 107-116
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Slowing the ramp to the label cadence (2.5 mg start, 2.5 mg steps, four-week holds) dropped that to mid-single digits at every maintenance dose, at no cost to the 12-week result, and the dedicated slow-titration trial reached placebo range. Reaching 15 mg is not the problem
It left them in a regulatory gray zone, no longer explicitly prohibited, but not yet authorized either
prolonging drug activity duration
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