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Nausea and GI side effects, which are most common during dose escalation, can persist longer than with shorter-acting drugs because the drug clears slowly
82204758) funded this study
10.1111/epi.12463 97 ZuoD.WangF.RongW.WenY.SunK.ZhaoX.et al (2020)
Last reviewed: May 15, 2026 Last updated: May 15, 2026 Written by: Jay Hastings , CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
It works by disrupting the FOXO4-p53 protein interaction that protects senescent cells from apoptosis
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