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Front Toxicol
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Zhang L, Hanigan MH
31,35-37 Prospective trials are needed to further explore this potential adverse event and worsened DR, which is the central premise of the ophthalmic FOCUS trial that is expected to release results in 2026
Even though the exact structure of the mPTP, as well as its assembly kinetics, is still unknown, interesting findings suggested that dissociation of F 1 F O ATP synthase dimers 45 and the c subunit pore-forming part 46 have an important role in mitochondrial permeability transition (mPT) and constitute a valid therapeutic approach in pathologies subjected to widespread cell death 47,48
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