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Underlying health conditions: Some health conditions, such as gastrointestinal disorders or liver disease, can affect B12 absorption and metabolism, potentially leading to shorter-lasting benefits from B12 injections
Downstream Cascade B Methionine-SAM Cycle and Epigenetic Regulation NNMT consumes SAM (the universal methyl donor) during NAM methylation
Patients who are truly deficient receive the treatment they need including injections when clinically warranted and patients who are not deficient are guided toward more appropriate solutions
Patients seeking weight management support should consult their GP for referral to NHS tiered weight management services, which provide evidence-based, multidisciplinary care
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