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Thats because were undergoing a major cultural shift over alcohol, and people just arent drinking as much anymore
In fact, Humiras reign was so dominant that it outpaced the next-highest drug (which happened to be Ozempic, a GLP-1) by tens of thousands of dollars
43 islets per mouse on average)
Reconstituted peptides degrade over time even under refrigeration, so knowing how old a vial is helps you interpret a fading response that might otherwise look like tolerance
Therefore, for now, it is better to focus on the conclusions that tirzepatide is safe from a cardiovascular perspective
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