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To directly address the glutathione depletion characteristic of ME/CFS and Long COVID, HM Complex provides a synergistic triad of N-acetyl-l-cysteine (NAC), l-methionine, and alpha lipoic acid (ALA)

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319 Furthermore, CAF-derived IGF-1 activates the IGF1R/Akt/mTOR/c-Myc pathway to upregulate QSOX2, reinforcing CSC phenotypes and therapy resistance