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This pharmacokinetic profile makes weekly dosing practical for patients, but individual metabolism rates vary significantly based on liver function, renal clearance, and body compositionfactors that clinical biomarkers can help quantify
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However, misuse can cause severe damage to the body, such as excessive weight loss with negative metabolic relapse, but also detrimental effects on the patients thyroid gland and psyche
Increased FFA in the liver results in insulin resistance, hepatic glucose production, and pancreatic beta cell dysfunction [7]
