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Collectively, these observations establish that NRF2 alone can sustain sufficient transcriptional output to maintain cancer cell line growth and that metabolic reprogramming of cells driven by NRF2 does not require redox buffering via enhanced glutathione production
An enzyme-linked immunosorbent analysis showed that the higher cytokine secretion levels of IFN-, TNF- and interleukin 6 (IL-6, a critical modulator of innate immunity) in the AP20187 treated group compared to age-matched vehicle-treated controls could be observed
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If the DNA damage is too severe or there is a defect in the DNA repair pathway, DNA repair will ultimately fail 5-7
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