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The higher dose provided a treatment intensification option with a similar safety profile for nearly a full year
Trying to "rev up" your system with GLP-1 medications while your thyroid is still underactive is like trying to drive a car with the handbrake on
A pragmatic way forward is to (i) use Bayesian inference to express uncertainty in clinically interpretable probabilities, and (ii) use data-driven phenotyping (including ML-enabled clustering where appropriate) to describe heterogeneity in treatment response
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