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Participants were randomly assigned to one of five therapies: exenatide alone, dapagliflozin alone, dual therapy of exenatide and dapagliflozin, combined dapagliflozin and metformin therapy, or the weight-loss medication phentermine/topiramate extended-release

Tirzepatide has an amphiphilic nature, meaning part of the molecule is water-loving and part is water-fearing (the C20 fatty acid chain)

Once pills exist, primary care physicians can prescribe them much more easily than if only injectables were options (as there are barriers to injecting pens in general practice)

(2016) reported that ABC overall scores evidenced no significant change after 6, 8, and 12 weeks of treatment, respectively

Several factors influence early weight loss outcomes: Starting dose and titration schedule : Lower initial doses produce less pronounced early weight reduction but are necessary to improve tolerability