Activation of Nrf2 leads to the upregulation of various antioxidant and detoxifying enzymes, enhancing the cellular defense against oxidative damage [213]
In addition, we observed that HIF-1 protein levels accumulate downstream of mTOR in response to GLP-1R signalling, whereas we also demonstrated that depletion of HIF-1 impaired effects on glycolysis and transcriptional regulation of glycolytic genes
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