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High-dose vitamin B12 supplements taken concurrently with the injection may lead to excessive B12 levels, though toxicity from vitamin B12 excess is extremely rare due to its water-soluble nature and efficient renal excretion

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When patients undergo blood tests, healthcare professionals may measure serum B12 levels when clinically indicatedfor example, if you have symptoms such as fatigue, neurological changes, or blood test abnormalities like macrocytosis