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Perspectives The pivotal discovery of GLP-1 was followed by the discovery of GLP-1 being a satiety hormone in humans acting on the brain and exerting a pronounced slowing of gastric emptying leading to weight loss

[11] It is not known whether sermorelin can cause fetal harm when administered to a pregnant woman or if it can affect reproductive capacity

Even more concerning, girls and mothers have told me they are turning to GLP-1s for shidduchim, to quickly lose weight before dating or a simcha, to appear more desirable to a partner, or simply to meet community and family expectations about body size

Factors influencing the outcome include individual metabolism, lifestyle choices and diet

These findings confirm that DMH GLP-1R neurons mediate pre-ingestive, cognitive satiation elicited by GLP-1R agonists, a phenomenon that we also observed in a human study [69]