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Key biomarkers: Acute (2-4h post-dose): Serum GH (ELISA, multiple time points) Weekly Chronicle: Total serum IGF-1 Body composition: DEXA scan (baseline, 4, 8, 12 weeks) Function Grip strength, treadmill performance Histology Muscle fiber analysis, adipocytes P: Compatibility with other compounds research

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122 This paradoxical response of SREBP-1c and ChREBP in hepatic IR is probably due to many branch effectors (including PI3K/AKT, AMPK, mTORC1, and FOXO1) involved in the hepatic glucose and lipid metabolism

Should I take supplements on an empty stomach or with food