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The tolerability profile is dominated by GI adverse events at higher rates than earlier-generation GLP-1s, with higher dropout at 12 mg than at 9 mg

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These hormone-based medicines, often grouped together as GLP-1 receptor agonists, slow how fast the stomach empties and signal the brain to reduce appetite, which is part of how this class of medicines is thought to work

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The dosage, adherence to a reduced-calorie diet, and other lifestyle factors can also influence the rate of weight loss