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However, as described earlier, its favourable effects on lipolysis and energy expenditure while reducing food intake make it an attractive option, especially if combined with the insulinotropic action of GLP-1

Possible effects on energy balance and body composition: Some data suggest modest improvements in energy expenditure and preferential loss of fat mass versus lean mass, but appetite suppression is the dominant driver of weight loss

32 It also significantly reduced the secondary composite HF endpoint (cardiovascular death, HF hospitalisation or urgent HF hospital visit), with an RRR of 18%

However, GLP-1 medications can also cause side effects such as nausea and dry mouth

Additionally, the CellChat function identifyOverExpressedGenes was applied to conduct a differential expression analysis of ligand-receptor pairs between the veh-LPS and veh-PBS treatment group as well as the comparison between the sema-LPS and the veh-LPS group