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Therefore, changes in melanocortin receptor density may underlie the differential response to MTII between rats on the fcHF and on the fcHFHS diet, but we cannot link these to changes in production of their ligands
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Conversely, meningeal ILC2s exhibit neuroprotective properties, particularly following CNS injury, by upregulating calcitonin gene-related peptide (CGRP) and other neurotrophic molecules, thereby contributing to tissue repair and inflammation resolution [182]
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In summary, this study demonstrated no benefit from six months of treatment with VPA and L-carnitine in a young non-ambulatory cohort of subjects with SMA
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