In depression, the inflammatory phenotype is particularly associated with atypical symptoms, including increased sleep and appetite, potentially leading to weight gain and local inflammation and macrophage infiltration in the adipose tissue, creating a self-perpetuating inflammatory loop [81]
GLP-1 receptor agonists reduce glucagon and glycogen secretion, inhibit appetite and slow gastric emptying [17] [18], creating a multifaceted approach to weight management that addresses both metabolic and behavioral components of obesity
1 in 5 Britons and 1 in 6 Americans said better sleep is an unexpected GLP-1 benefit
Hashimoto's disease itself does not fall into these categories, but patients should be counselled about this theoretical risk
Saxenda delays gastric emptying, which could theoretically affect absorption of oral medications, though clinically significant effects on sertraline are unlikely