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A WADA-funded Ghent University project identified the active content of a commercial TB-500 product as this acetylated seven-residue fragment

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In high L-arginine-dependent tumors, such as breast cancer (Abdelmagid et al., 2011), CRC (Lu et al., 2013), and HCC (Kishikawa et al., 2015), increased expression of the transporter CAT-1 ( SLC7A1 ) has been observed, and CAT-1 ( SLC7A1 ) knockdown decreases the viability of cancer cells and induces apoptosis