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Autism Dev Disord
19 Substitution with Aib 8 hardly influences the cAMP activity and substitution with D-Ala 8 induces little or no change in the affinity or cAMP activity
Abbreviations BCAAs: Branched-chain amino acids CIs: Confidence intervals DR: Dorsal raphe fMRI: Functional MRI GLP-1RAs: Glucagon-like peptide-1 receptor agonists GWAS: Genome-wide association studies IGF: Insulin-like growth factors IR: Insulin receptor IVW: Inverse-variance weighted LD: Linkage disequilibrium LIRA: Liraglutide LPS: Lipopolysaccharide MDD: Major depressive disorder MHC: Histocompatibility complex MR: Mendelian randomization OCD: Obsessive-compulsive disorder ORs: Odds ratios PGC: Psychiatric genomics consortium RCTs: Randomized controlled trials T2DM: Type 2 diabetes mellitus UKB: UK biobank References U.S
The usual mechanistic explanation is that the GHRH arm drives somatotroph cAMP signalling while the GHRP arm additionally attenuates somatostatin tone, so the two are acting on different limbs of the same axis rather than competing for one receptor
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