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The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent Research Center, based at the University of Copenhagen, Denmark, and is partially funded by an unconditional donation from the Novo Nordisk Foundation (www.cbmr.ku.dk) (grant numbers NNF18CC0034900 and NNF23SA0084103)

GLP-1 receptor activation is the foundation: it slows gastric emptying, reduces appetite by acting on hypothalamic satiety centers, and stimulates glucose-dependent insulin secretion

Weight loss typically accelerates during this period, with most researchers reporting 4-8% body weight reduction by week 12

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Sterile water is an alternative but lacks the preservative, meaning the solution must be used more quickly