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Key evidence points: GLP-1 medications do not directly target or break down muscle tissue Lean mass loss occurs as a consequence of the calorie deficit and weight reduction The proportion of lean mass lost is comparable to other weight loss methods Greater absolute lean mass loss reflects the greater total weight loss achieved Regulatory bodies including NICE and the MHRA have not identified muscle loss as a specific adverse effect requiring special warnings in the Summary of Product Characteristics (SmPCs), though healthcare professionals are advised to monitor nutritional status and encourage appropriate dietary protein intake and physical activity in patients using these medications for weight management
As a consequence, the stimulation of GLP1R is considered an attractive means of treating type 2 diabetes
While supplements can play a role in supporting overall health, individuals with Hashimotos or hypothyroidism need to be particularly cautious
This was not Pfizers first or last oral GLP-1 disappointment
Ther Drug Monit
