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doi: 10.1056/NEJMoa1509225 98 HernandezAFGreenJBJanmohamedSDAgostinoRBSr.GrangerCBJonesNPet al

Leptin acts on the hypothalamus (control center) in the brain, causing reduced food intake and burning of fat stores for energy (Meister 2000

Additional information How to cite this article: Jiang, X

Stirban A, Gawlowski T, Roden M

Hu, The Lancet Diabetes & Endocrinology, February 25, 2026, doi: 10.1016/S2213-8587(25)00395-X The study was based on data from the Million Veteran Program, Office of Research and Development, Veterans Heath Administration, and was supported by the Veterans Administration MVP awards #000 and #001