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Sensitivity analyses using leave-one-out models and exclusion of high-risk-of-bias studies confirmed the robustness of the findings, as the direction and magnitude of effects remained unchanged across iterations

Those who stayed on the treatment lost about 17% of their body weight compared with patients who received a placebo, who lost about 3% of their body weight

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Indeed, loss of GPX4 expression and activity specifically in monocytes/macrophages triggers ferroptosis in IL-4-driven macrophage differentiation, while sparing inflammatory macrophages, which were able to sustain cell survival and function in the absence of GPX4

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