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Insider's takeaway The Institute of Medicine has not established a tolerable upper intake level of B12 because studies show no adverse health effects when taking excess levels of B12, either through food or supplements

People with demanding lifestyles those with high-stress, high-activity or high-output lifestyles place greater demands on their nutritional resources

Avoid refrigerating unless the product label specifies otherwise, as temperature cycling can stress the vial seal

If a supplier insists on acetic acid reconstitution without a solubility justification, that is a product quality flag