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Mechanism studied Tesofensine is characterised in the literature as a triple monoamine reuptake inhibitor , examined for its interaction with the serotonin (SERT), noradrenaline (NET) and dopamine (DAT) transporters

Research demonstrates tesofensine increases 24-hour fat oxidation by approximately 15% while reducing protein oxidation, indicating a favorable shift in substrate utilization toward lipid metabolism

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