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While no formal randomized controlled trials have yet validated microdosing protocols, clinicians may cautiously individualize dosing for patients who benefit from gradual escalation or maintenance at intermediate doses

Importantly, wild-type BoNT/X protease did not induce notable apoptotic or lytic cell death (Extended Data Fig

it's thiol group oxidation driven by dissolved oxygen in the reconstitution medium

Lastly, the thematic analysis was carried out, to synthesize and interpret all the data that appeared from the included publications