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For diabetes treatment, NICE recommends continuing GLP-1 therapy only if HbA1c has fallen by at least 11 mmol/mol (1%) and weight has reduced by at least 3% after approximately 6 months, unless there are individual clinical reasons to continue
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Given the short timeframe of the GLP-1 demonstration, it is unlikely that there will be cost offsets from improved health due to increased GLP-1 use for obesity that can be documented
References: HIGHLIGHTS OF PRESCRIBING INFORMATION, Accessdata.fda.gov,
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