Gastroenterology 73 , 13771382 (1977)
However, this reaction mechanism is not plausible since the formation of two hydroxide ions at pH = 7.4 requires in terms of free energy, taking into account the experimental pK a = 15.7 value for water molecule (Bronsted, a value of 9.58 (Young and Babbitt, 1983), therefore protonated amino group (-) deprotonation cost in terms of free energy equals to .The numerical procedure to locate the transition state and calculate the activation-free energy failed
Clin J Pain 18:270273 Laske C, Stransky E, Eschweiler GW, Klein R, Wittorf A, Leyhe T, Richartz E, Khler N, Bartels M, Buchkremer G, Schott K (2007) Increased BDNF serum concentration in fibromyalgia with or without depression or antidepressants
(PubMed) Ziegler D, Low PA, Freeman R, Tritschler H, Vinik AI
S., Mani, H., Banaudha, K., Maheshwari, R