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Loading phase uses higher doses (2.5-5mg) 2x weekly for 4-6 weeks to rapidly saturate tissues and initiate healing
The 20-30 hour half-life means the peptide still distributes systemically regardless of site, so any local-only effect is partial at best
GHK-Cu operates differently
Tesamorelin signals the pituitary gland to release growth hormone, which raises IGF-1 levels and preferentially mobilizes visceral fat, an effect that is typically assessed over months rather than weeks
Ipamorelin is discussed as interesting because it appears to engage the intended receptor pathway more selectively than older, broader secretagogues
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