Maridebart cafraglutide (a monthly GLP-1 in trials) addresses this by using an IgG scaffold to harness the natural FcRn recycling pathway for around a two-week half-life
For Zepbound specifically, there is no established direct causal link to vision problems in the general population using the medication for weight management
Mahtab Jafari, Professor of Pharmaceutical Sciences and Ecology & Evolutionary Biology at The University of California, Irvine, and Founding Director of the UC Irvine Center for Healthspan Sciences
While one pilot study showed two people tolerating 20mg intravenously, that does not guarantee that long-term daily injections are safe
PubMed 22962027 TB-4 Phase 1 human safety first-in-human randomized, double-blind, single- and multiple-dose Phase 1 of recombinant human thymosin 4 in healthy volunteers, no serious adverse events: PubMed 34346165