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The activity of SLC7A11 is regulated by several factors, such as the transcription factor activating transcription factor 4 (ATF4) and/or nuclear factor erythroid 2-related 2 (NRF2) [33, 34], the epigenetic regulation-associated enzyme BAP1 [35], the tumour suppressor protein p53 [36], the autophagy mechanism component BECN1 [37], and the ferroptosis inducer erastin [38]
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In extrahypothalamic regions, GHSR 1 a is expressed predominantly in the hippocampus , and in dopaminergic midbrain neurons
The developing nervous system appears to be especially vulnerable to vitamin E deficiency
The FDA says there is no legal basis for selling the compound as a drug, supplement, or food (though there is evidence for its illicit sale and use) (14)
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