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Their work underscores that the problem is biological, not behavioral
Cycles often stabilize once weight loss slows and the body adapts metabolically
Unlike broad anti-inflammatory drugs, senolytics work by exploiting the unique survival dependencies of senescent cells, targeting pro-survival pathways such as BCL-2/BCL-xL, PI3K/AKT, and HSP90 that senescent cells upregulate to resist apoptosis
A consensus report by the American Diabetes Association (ADA) and the European Association for the study of diabetes (EASD)
14,15 Because of the results of these landmark clinical trials, evidence-based treatment guidelines now recommend the GLP-1/GIP agonists as an important second-line treatment for uncomplicated type 2 diabetics who fail to meet hemoglobin A1c targets on popular first-line agents such as metformin
