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Genetic ablation of glutathione synthesis in Tregs leads to severe multi-organ inflammation, demonstrating glutathione's critical role in immune homeostasis
doi: 10.1210/jc.2011-2407 209 AlvesCBatel-MarquesFMacedoAF
This conservation is not surprising as oxidative stress is an inevitable byproduct of aerobic respiration, and GSH is an important antioxidant that mitigates the effects of reactive oxygen species (ROS), such as hydrogen peroxide
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