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Polyphenols are also subject to various denaturing conditions (103), such as heat, light, oxygen, pH variations, and enzymatic degradation, which reduce their bioavailability and limit their efficacy as bioactive compounds (108)
Nature 404:661671 Elmquist JK, Bjrbaek C, Ahima RS, Flier JS, Saper CB (1998) Distributions of leptin receptor mRNA isoforms in the rat brain
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