They are signaling molecules, neurotransmitters, infection-fighters, and growth factors that promote tissue repair and healing
HAP, through its positively charged calcium units establishes chemical links with skin unsaturated fatty acids carboxylic groups, leading to their subtraction from skin surface (-43%), hence avoiding their exposure as substrates for the formation of ROS resulting from skin lipid peroxidation Despite its activity on skin unsaturated fats adsorption, hydroxyapatite does not affect skin sebometry, keeping a balanced equilibrium of the skin hydrolipidic film (analysis carried out through sebumeter SM 815, results are summarized in figure 3) with a consequent lack of comedogenic and pores clogging potential
Renal effects are primarily related to volume depletion from gastrointestinal side effects rather than direct nephrotoxicity
Spicy foods can irritate the gastrointestinal tract and worsen reflux or nausea in some individuals, particularly in the early weeks of treatment
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