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At the same time, it tells the pancreas to make less glucagon, cutting down spikes in blood sugar

Elahi et al.Obesity (Silver Spring)

Novo Nordisks own indirect treatment comparison (the ORION study, presented at Obesity Medicine Association 2026) suggested greater weight loss with oral semaglutide than with orforglipron, though that analysis was industry-funded and drew skepticism from independent researchers

adults with the same age and gender distribution as GLP-1 users, who consider themselves overweight and are not currently using a GLP-1 medication) to go out to eat to socialize specifically, suggesting that users of the medication see the experience as one that isnt just about the food

Semaglutide is one of the best new tools in his toolkit to help free his patients from the cycle of weight gain and obesity and the associated health risks excess weight brings