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10.1038/srep27610 98 LiuQ.LuJ.LinJ.TangY.PuW.ShiX.et al (2019)
The phase 2 study in type 2 diabetes patients showed significant appetite reductions, but the overall weight loss was slightly lower than in the obesity-only trial (16.9% versus 24.2% at the highest doses over comparable timeframes)
In vitro assay designs that isolate GLP-1R and GIPR signalling from GCGR signalling for example, using receptor-selective antagonists are one methodological approach used to attribute observed effects to each receptor arm
The group achieved a median 8.8% total body weight loss at six months, recovering roughly two-thirds of their post-surgical weight regain
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