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17 The TAD is a disordered binding region for a larger cohort of interacting proteins, including molecules involved in the transcriptional machinery, the negative regulators MDM2/4, and the transcriptional coactivators p300/CREB-binding protein (CBP)

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Changes in bowel habits that are severe or persistentsuch as bloody stools, black tarry stools, or diarrhoea lasting more than a few daysrequire medical evaluation to rule out other causes

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