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It is likely that the larger number of statistically significant changes to the microbiome observed in the groups switched from WD to LD reflects their more numerous exposures to different diets, longitudinal changes in dietary exposure, the stress associated with diet switch, the negative energy state achieved by treatment and/or diet-driven weight loss, or a combination of these factors, but it may also be related to differences in terminal body weight and fat mass since both adiposity and diet composition have been shown to modulate the mouse gut microbiome profile
Production Methodology & Quality Controls AOD-9604 is synthesized using solid-phase peptide synthesis
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This has opened new avenues for treatment, offering hope for improved management of chronic diseases
It is not approved for human consumption or clinical use
